Medicalnews – Kasus penyakit asam lambung atau GERD di Indonesia terus meningkat setiap tahun.
Pola hidup penuh stres dan konsumsi makanan berkalori tinggi menjadi pemicu utama.
Ketua PB Perhimpunan Gastroenterologi Indonesia, Ari Fahrial Syam, menyebutkan obat terbaru bernama Fexuprazan sebagai pilihan terapi baru.
Obat ini termasuk dalam kelas Potassium-Competitive Acid Blocker (P-CAB) dan bekerja berbeda dari terapi lama.
“Baca Juga: Tips Diet Sehat: Turunkan Berat Badan Tanpa Ganggu Metabolisme“
Perbedaan P-CAB dengan Terapi PPI
Selama ini, dokter meresepkan Proton Pump Inhibitor (PPI) sebagai terapi utama GERD. Namun, P-CAB bekerja lebih cepat dan lebih fleksibel dibanding PPI. Ari menjelaskan bahwa P-CAB menekan produksi asam lambung sejak dosis pertama. Sebaliknya, PPI baru menunjukkan efek optimal setelah tiga hingga lima hari penggunaan rutin. Selain itu, P-CAB menjaga produksi asam tetap terkendali hingga 24 jam penuh.
Keunggulan P-CAB Dibanding Terapi Lama
P-CAB menawarkan beberapa keunggulan bagi pasien GERD.
Pertama, pasien bisa mengonsumsi obat ini kapan saja, baik sebelum maupun sesudah makan.
Pasien tidak perlu mengikuti jadwal ketat seperti pada terapi PPI.
Kedua, P-CAB efektif menekan asam lambung di malam hari.
Hal ini penting karena banyak pasien mengalami gejala kambuh saat malam.
Selain itu, P-CAB menjaga kestabilan pH lebih lama sehingga tidur pasien menjadi lebih nyaman.
Efek Samping yang Lebih Ringan
P-CAB juga memiliki risiko efek samping yang relatif ringan.
Beberapa efek yang mungkin muncul adalah mual, nyeri perut, atau sakit kepala.
Namun, efek tersebut tetap lebih ringan dibandingkan efek samping PPI. Terapi PPI bisa menimbulkan gangguan ginjal, fraktur, hingga infeksi usus. Karena itu, banyak ahli menilai P-CAB lebih aman untuk penggunaan jangka panjang.
Hasil Uji Klinis di Jakarta
Ari menjelaskan hasil uji klinis di tiga rumah sakit besar di Jakarta.
Obat P-CAB terbukti meredakan gejala GERD lebih cepat hingga lima hari dibanding PPI.
Selain itu, pasien melaporkan peningkatan kualitas hidup setelah terapi ini.
Keberhasilan tersebut memberi harapan baru bagi pasien yang kesulitan dengan terapi lama.
Perubahan Gaya Hidup Tetap Penting
Meski obat baru menjanjikan, Ari menekankan pentingnya perubahan gaya hidup.
Dokter menyarankan pasien untuk berhenti merokok, mengurangi alkohol, dan menghindari makanan berlemak.
Selain itu, pasien sebaiknya membatasi cokelat, keju, kopi, serta minuman bersoda.
Langkah ini membantu mengurangi kambuhnya GERD dan mencegah komplikasi jangka panjang.
Fexuprazan Masih Menunggu Izin di Indonesia
Chief Medical Officer Daewoong Indonesia, dr. Stella Melisa, juga menanggapi peluncuran obat ini.
Menurutnya, Fexuprazan merupakan bagian dari strategi global perusahaan menghadirkan inovasi medis.
Namun, obat ini belum tersedia secara luas di Indonesia.
Pihak perusahaan masih menunggu izin edar dari Badan Pengawas Obat dan Makanan (BPOM).
Stella yakin, setelah mendapat izin, Fexuprazan akan menjadi solusi penting bagi pasien GERD.
“Baca Juga: Vape Dinilai Lebih Efektif Bantu Perokok Berhenti“

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Testosterone is the hormone linked to muscle development, bone density, and
lots of male characteristics. Inside the medical field, doctors
generally prescribe oxandrolone to assist in weight recovery after prolonged sickness or surgical procedures.
The drug also can relieve some forms of bone ache associated to osteoporosis and gradual muscle loss for patients on particular medicines.
In distinction to anabolic steroids, a woman’s dose of clenbuterol is typically similar to a man’s.
In this cycle sample, the Anavar dose of 20 mg/day is maintained for eight weeks.
This dose is usually adopted by individuals who have previously taken Anavar or other
anabolic steroids.
Meanwhile, utilizing other steroids usually multiplies toxicity issues, particularly for
the liver. Those with diabetes should be conscious that Anavar may have an result on blood sugar management, a proven truth that makes frequent glucose checks essential.
Always inform your doctor about every complement,
herb, or prescription you take to attenuate hazards.
It’s necessary to understand that Anavar is a reasonably weak anabolic
steroid and it’s not going to produce the same types of results
as different steroids corresponding to testosterone or Dianabol.
Moreover, Anavar may be quite expensive and it’s not all the time easy
to discover a dependable source. The timing of Anavar’s
administration is dependent upon various components, together with your personal schedule before and after anavar male
preferences. Nonetheless, contemplating its brief
half-life, splitting the dosage all through the
day may help preserve constant levels in your system.
Consult with your healthcare professional or follow
the guidance offered by your prescribing physician. Some individuals
prefer taking Anavar roughly 30 to 60 minutes earlier than their exercise to capitalize on its
performance-enhancing properties during training.
Whereas the standard dosage range is a good start line, keep in mind that safe and efficient dosages could be influenced by
a quantity of elements. Each particular person is completely different, and what works for one individual
may not work for one more. So, you’ve heard so much about the advantages
of this sure steroid and you’re fascinated, but you’re also smart.
You know that understanding how a lot to take is just as essential as understanding what
you’re taking. If you’re in search of recommendations of how
a lot do you’ve got to take or factors to suppose about
for the dosage, you’ve come to the best place.
Some dealers promote Dianabol under the alias Anavar as a advertising ploy.
Because Dianabol considerably increases the chance of virilization, it is
a downside for girls.
This testosterone-to-estrogen balance appears necessary for avoiding a masculine look.
One good factor about injecting Primobolan is that it may have
a less adverse impression on levels of cholesterol.
Blood strain could be very unlikely to skyrocket on Primobolan, although
ladies ought to continually monitor it during a cycle.
It is favorable among girls due to its low androgenic
rating (44-57), thus inflicting a low danger of virilization. Women might
notice a delicate decrease in natural testosterone from taking Anavar, plus some unfavorable
shifts in cholesterol; nonetheless, such effects are solely more doubtless to be delicate.
High doses (above 10 mg) are unnecessary, as some ladies have even reported favorable outcomes from taking tiny doses of two.5 mg
per day.
LDL cholesterol levels will almost certainly rise, with
HDL levels changing into suppressed. Winstrol isn’t suitable for beginners because of the severity of unwanted effects that are
usually experienced. Winstrol dosages for men are sometimes 50 mg per day however can go as high as double that.
Nonetheless, this isn’t to say it’s only used by women, with a quantity of male powerlifters and bodybuilders
additionally using Anavar to good effect.
Nevertheless, like with any potent fitness software, it’s necessary to leverage their energy with care, considering all health considerations in concert with one’s general
health strategy. Winstrol is the extra highly effective steroid and
outcomes are likely to be slightly higher; with customers building barely extra muscle, in comparison with Anavar.
Nevertheless, it might be used as a secondary compound
when stacked with more potent muscle mass builders like Dianabol or Testosterone.
This is due to Winstrol rising free testosterone, with
it strongly binding to SHBG (sex hormone-binding globulin).
When free testosterone levels turn out to be excessively elevated
in women, masculinization follows. Nevertheless, it typically causes virilization unwanted effects, inflicting girls to look and sound
extra masculine.
This creates a giant and tight look rather than a big, bloated mess look.
On the flip side, if your cortisol levels drop considerably, you’ll find a way to anticipate enhanced fats burning…and that’s exactly what
Anavar does. If you’re looking for safer ways
to attain similar outcomes, authorized Anavar options like Anvarol may supply a viable, side-effect-free possibility.
Anavar (Oxandrolone) is a Schedule III controlled substance in the us and requires
a prescription.
Nonetheless, because of Winstrol’s superior muscle-building attributes, this distinction in glycogen storage may not be noticeable.
If you go longer than that, you’re risking excessively excessive LDL cholesterol levels.
This creates an even more enhanced look, with increased muscle tone and definition. However, if ladies take extreme doses for long periods
of time, virilization unwanted effects with Anavar alone are still potential.
For official regulatory info on anabolic steroids,
see the FDA’s guidelines on anabolic steroids.
Every lady has muscle, nevertheless, when you have subcutaneous fats masking the muscle it will be exhausting to
see the muscle definition. Not Like many different anabolic
steroids, Anavar just isn’t recognized for inflicting vital water retention. This is
doubtless one of the reasons why it’s favored for cutting cycles, where the aim
is to attain a lean, defined physique. Anavar and Winstrol possess many
similarities, with both lowering fats mass and water retention while
rising lean muscle mass. The data provided on this website
is for academic functions only and isn’t intended as medical recommendation.
Joseph P. Tucker is a co-founder of this tiny area,
a husband to a wonderful spouse, and a fitness fanatic.
He is enthusiastic about serving to others obtain their
health and wellness objectives, and he loves nothing more than spreading
the gospel of health and vitamin throughout the online.
While Anavar is extremely in style due to the low amount of
side effects and lack of estrogenicity, it’s still an illegal compound by each WADA (world anti-doping
Agency) and the legislation. As with any drug, there might be side effects, especially at larger doses.
For max features, you’d want to add another
compound that converts into Estrogen, as Estrogen is barely anabolic and can help with
positive aspects.
Anavar became utilized as a slicing steroid on the expense of some users experiencing cardiotoxicity (heart toxicity)
and hepatotoxicity (liver toxicity). I’m four weeks in on Ostarine (10 mg/day), LGD-4033 (10 mg/day), and MK-677 (20 mg/day).
My weight has elevated by 8–10 lbs, and my power and endurance are at an all-time
high for me. I’m considering rising the Ostarine and MK-677 by 10 mg for more
optimal gains, however I’m unsure if it’s value
it. The subject gained 5 pounds in weight, which could be partly attributed to a small calorie surplus from their food regimen.
Maintain in mind that using these substances collectively can improve the
potential for unwanted effects and health dangers, so
medical supervision is essential. Health Club ‘ll flip into enthusiasm, dull exercising can change into thrilling.
Steroid treats and boosts, gear could be multifaceted, its range can be practically unlimited.
If any type of dietary supplements fade away ‘ A’s maintain powerful charge, stay longer.
To enhance size embody aromatized anabolics, take androgenic drugs for base, like Testosterone Combine.
Add on dependable A’s like Turinabol for getting good high
quality, not water lbs. In case you want to obtain overall health positives whereas having enchancment ‘ define your primary intentions rigorously.
This is a novel impact compared to other anabolic steroids, which usually lower subcutaneous fats while growing visceral fat (5).
Anabolic steroids are synthetic substances that mimic the results of natural
testosterone. Anabolic steroids, notably these with androgenic effects, can stimulate the
growth of facial hair in each and girls. This is due to increased levels of androgens, corresponding to testosterone
which promote the development of male characteristics.
The development appears to be the most pronounced around the higher lip space.
It has even been recognized to look on the forehead of
the steroid person. There is research to suggest steroids
DO have a permanent effect when tested in mice.
Regardless Of medical functions, Anavar is commonly abused for its capacity to construct
muscle and scale back physique fats. Such off-label use
can spur dangerous reactions, so it’s necessary for anyone contemplating the drug to thoroughly understand its potential advantages and risks.
Anavar (oxandrolone) is a broadly used anabolic steroid,
often praised for its muscle-building properties.
Whereas some view it as a gentler different to other performance-enhancing substances, it
still carries critical well being concerns, particularly if misused.
Users might expertise slight modifications in muscle
tone and physique composition, however these
adjustments will probably plateau shortly with out the stimulus
of training. The actuality is that Oxandrolone is on no account an various to onerous blood work before and after anavar hdl ldl, however rather a software to enhance it.
Many ladies, particularly health fashions, attain stunningly sculpted and outlined physiques with simply 5-10 mg every day.
A patient of ours skilled a hernia after performing tricep pushdowns whereas stacking Anavar with Anadrol.
His energy increased considerably in a brief area of time, and thus, the risk of harm can improve
from taking Anavar or different anabolic steroids.
By the tip of the primary month, you must be at your peak outcomes, with a extremely defined and shredded physique and
a big increase in power. Wrap that cycle, permit your body a considerable rest period,
and reflect in your progress. Over 6-8 weeks for men and weeks for girls, you
would likely observe a big distinction compared
to earlier than you started the cycle. Outcomes are regularly
delayed, and the timeline can alter based on varied elements.
It’s necessary to notice that extending cycles past 12 weeks necessitates the addition of a testosterone base and the incorporation of
liver assist supplements. In the case of children, the whole daily dosage of Oxandrin (oxandrolone) mustn’t exceed ≤ 0.1 mg per kilogram of physique weight or ≤
zero.045 mg per pound of body weight.
There’s rather more to know concerning the side effects of Anavar and all anabolic steroids, so go to my main unwanted side effects information here.
These long-term unwanted effects are much more likely to come back about from another extra highly
effective steroids you could be stacking Anavar with quite than from Anavar itself.
This is more of a sophisticated cycle as we’re stacking two oral AAS, which
comes with dangers.
Nonetheless, it’s essential to reiterate that the potential for side effects
must be rigorously evaluated and monitored. The usage of this
potent substance should be accomplished judiciously, with a concentrate on figuring out the suitable dosage and period for each individual’s
distinctive wants and targets. Anavar, a preferred
anabolic steroid, has garnered consideration for its potential to promote muscle
gains, enhance strength, and assist in fats loss. While everybody’s body responds in another
way, two weeks is usually considered an important
milestone to evaluate preliminary progress and glimpse the transformation that Anavar can facilitate.
At All Times work with a healthcare provider
when making dose changes — self-adjusting can lead to inconsistent results or side
effects. Some individuals report a tingling or pins-and-needles sensation in their fingers,
toes, or extremities. This could also be as a outcome of shifts in fluid
stability or elevated nerve sensitivity triggered by greater HGH levels.
Whereas not harmful generally, it’s price
mentioning to your supplier — especially if it persists past
the primary few weeks.
The enhanced restoration properties of Ipamorelin enable athletes and bodybuilders to bounce again quickly from
intense workouts, lowering the danger of overtraining and harm.
This peptide not solely aids in physical efficiency but also contributes to general well-being and stamina.
Following the prescribed cycle helps the body regulate to the peptide’s
effects progressively, lowering the risk of tolerance development.
Consistency in sticking to the cycle period allows for sustained progress in muscle acquire and body fats reduction. When Sermorelin and Ipamorelin are used collectively,
they work in tandem to stimulate the pituitary gland, prompting the discharge of
growth hormone (GH) extra successfully than when used individually.
When Ipamorelin interacts with the expansion hormone-releasing peptide (GHRP) receptors, it stimulates the discharge of growth
hormone from the pituitary gland.
In a research in the Archives of Neurology, adults who were given GHRH remedy
had improved cognitive perform after 20 weeks of remedy.
GH therapy didn’t induce an extra improve in insulin levels during an oral glucose tolerance take a
look at (OGTT) but considerably decreased free fatty acid (FFA) ranges during OGTT.
We aimed to judge whether or not weekly administered low dose
of sustained-release rhGH (SR-rhGH) might play a therapeutic role within the therapy of belly weight problems.
Most studies have used supraphysiological doses of rhGH, which have been administered day by day or each different
day. IGF-1 performs an important role in cell growth, muscle restore, and total tissue
health.
For bodybuilders particularly combining Ipamorelin with CJC-1295 (a frequent
peptide stack), the perfect dosage is reported to be 300 mcg of Ipamorelin and 250 mcg of CJC-1295 per day.
It increases progress hormone with out affecting different hormones
like cortisol or prolactin. Bodybuilders appreciate this
targeted method since it reduces undesirable unwanted side
effects. This Ipamorelin guide examines the optimal
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peptide regimen. We’ve also included a easy dosage calculator and chart for quick reference.
Join our daily All About Peptides newsletter for expert recommendation on improving
your health and hitting your fitness goals. Going
overboard with Sermorelin can result in plenty of unwanted
unwanted side effects.
To address injection web site reactions, the applying of a chilly compress can help in mitigating
swelling and discomfort. Sufficient hydration and relaxation are recommended to alleviate headaches and flu-like symptoms.
In case of severe unwanted aspect effects, similar to allergic reactions or
respiratory difficulties, immediate medical intervention must be sought.
We may even talk about the dosage, administration, and the place to buy this effective mix.
Whereas it could assist certain regenerative processes within the physique, it’s essential to have
practical expectations and not rely solely on this peptide as a sole means of regenerative drugs.
This makes it a well-liked alternative for these looking to
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Gathering feedback and comments on Ipamorelin CJC 1295 user experiences, unwanted
effects, and peptide stacking practices can provide useful
insights for optimizing outcomes.
This makes Sermorelin safer, extra natural, and easier to
regulate for long-term use. For long-term users, a break of 1–2 months after a 3–6 month cycle
is commonly beneficial. This helps prevent receptor desensitization and retains
the pituitary gland responsive.
In this research, ipamorelin was administered via intravenous
infusion on postoperative days 1 to 7. Researchers noted that ipamorelin was “well-tolerated” by take a look at subjects
and produced no critical adverse occasions (AEs)
13. Whereas it may be purchased as a reference material,
it has not been permitted for human analysis and there are no clear pointers for how it must be dosed or administered.
While this research could seem encouraging, ipamorelin presently has no officially recognized makes use of.
This suggests that additional research, particularly well-designed, long-term clinical trials,
may be warranted. The majority of the analysis carried out
on ipamorelin’s benefits has taken place in lab settings on nonhuman animals.
Research data from human trials is lacking and ipamorelin has yet to
pass part II trials.
Protein intake, particularly before sleep, may help muscle protein synthesis through the
GH-rich overnight interval without the same
GH suppression seen with large carbohydrate hundreds. Ipamorelin is secure and effective
for girls when dosed appropriately. Most
customers run 8–12 week cycles, although some protocols lengthen to 16–20 weeks when used for longevity or damage restore.
Sermorelin Acetate, through its mimicry of the natural
development hormone-releasing hormone, stimulates the pituitary gland
to synthesize and launch endogenous growth hormone.
This mechanism renders it an effective remedy possibility for growth hormone deficiencies in both
pediatric and adult populations. By adhering to those precautionary protocols,
healthcare professionals can preemptively tackle any challenges which will arise
and optimize the therapeutic outcomes of Sermorelin Acetate
and Ipamorelin therapy. The mixture of Sermorelin Acetate and Ipamorelin in a therapeutic regimen usually requires a custom-made dosage plan that
considers the patient’s individual well being requirements and response to therapy.
This course of commences with a thorough patient analysis to collect important
info such as medical historical past, present medicines, and any underlying well being conditions.
It’s essential to notice that Sermorelin just isn’t growth hormone itself; rather, it acts as
a signal peptide. By binding to receptors in the pituitary
gland, it stimulates your body’s natural production of growth hormone.
Sermorelin, functioning as an analog of Development Hormone-Releasing Hormone
(GHRH), is instrumental in regulating and stimulating the pure manufacturing of development hormone
within the physique. The precision of dosing not solely
optimizes therapeutic outcomes but in addition safeguards towards potential unwanted effects.
Sermorelin is among the most generally used progress hormone–releasing peptides,
favored for its capacity to soundly and naturally improve your
body’s own progress hormone (GH) production. But identical
to any performance-enhancing protocol, dosage is every little thing.
Timely reporting of adverse reactions is crucial as it allows swift reactions from
regulatory bodies and healthcare professionals to deal with potential safety issues.
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Compounding or internet sales do not ensure high quality, sterility,
correct identity, or legal compliance. If
a clinician proposes ipamorelin, ask about actual sourcing, batch testing, documentation, and monitoring plans—including IGF-1
targets and glucose surveillance. In short-term research and inpatient use,
ipamorelin has shown a suitable security profile at studied doses.
It helps physiologic peaks at night time and decrease ranges through the
day. Many adults prefer this profile, especially when they need healthy aging rather than a rapid but
risky surge. These steps increase gradual wave sleep and assist the peptide do more with less.
Long-term, outpatient safety—especially with compounded products
and combinations—remains under-characterized and calls for caution. In analysis settings, secretagogues usually produce bigger
GH increments when administered in a post-absorptive state (for
instance, a few hours after the final meal) than immediately after a high-glycemic meal.
Protein intake, significantly before sleep, may assist muscle protein synthesis during the GH-rich in a single
day period with out the same GH suppression seen with massive carbohydrate masses.
Because ipamorelin reliably will increase GH (and often IGF-1 downstream),
it may affect lean mass accrual, restoration from
catabolic stress, bone turnover, sleep architecture, and urge for food.
The short half-life and receptor selectivity additionally make it an interesting software to review GH pulses without chronically elevating
cortisol or prolactin. At the receptor stage, ghrelin agonists need the receptor’s distinctive binding pocket that
recognizes ghrelin’s acyl modification.
After injecting Ipamorelin, your pituitary gland will secrete development
hormone and this helps each muscle progress and development.
It is amongst the most secure and handiest development hormone-releasing peptides (GHRP) in existence because it does not have
an result on the release of different hormones within the physique such as cortisol and acetylcholine.
Understanding the right dosage and reconstitution course of is essential
for reaching the desired therapeutic outcomes.
sermorelin ipamorelin results is regularly
in comparison with different development hormone–stimulating peptides like CJC-1295, Ipamorelin, and Tesamorelin. Whereas all
of those compounds work to extend progress hormone or IGF-1
levels, they differ in how they act, how long they final, and the
way they’re finest used. While Sermorelin is considered one of
the safest peptides for exciting natural GH manufacturing, incorrect dosing or poor administration habits can still lead to undesirable
unwanted effects. To maximize results, Sermorelin should be administered at evening, simply before mattress,
and on an empty abdomen.
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For sustained results, contemplate a period of 3 to six months of
constant use. Begin low and regulate as your body adapts,
beneath professional steering. Dosing regimens for CJC-1295 DAC sometimes suggest 2 mg per
week, divided into a quantity of administrations.
Blood checks are usually performed each few months to track progress.
Even small variations in dose can affect how your body
responds. Always observe your prescribing physician’s guidance and keep away from adjusting your dose without medical input.
Tell your doctor if you have ever had any unusual or allergic reaction to this drugs
or some other medicines. Also inform your health care skilled if you have any
other types of allergic reactions, corresponding to to meals, dyes, preservatives, or animals.
Whereas Ipamorelin works on the level of the abdomen to help increase progress hormone.
Getting the most out of Sermorelin isn’t just about
using it — it’s about utilizing it accurately. Whether your objective is to spice up recovery, improve fats
loss, support anti-aging, or construct lean muscle, the
best dosage and timing make all of the difference.
Monitoring your body’s response and adjusting the dosage accordingly is key
for optimum muscle growth and restoration without bringing about any undesirable side effects.
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